Captain Jacob Keyes started to have bad luck from the first moments of Halo 1. His ship, preparing for a secret mission, was ambushed when the Covenant attacked Reach. They fled blindly, only to arrive at Halo 04 and find the Covenant waiting for them. After a valiant effort, the ship crashes on Halo and Keyes is taken prisoner.
The Master Chief and Cortana mount a daring rescue, so the player has to get inside a Covenant cruiser, find the captain, and keep him alive until the end of the level.
Almost immediately after, however, the captain's search for hidden weapons to use against the Covenant lead to the discovery of the Flood, who take him captive for the second time in the game. The Chief's second valiant rescue attempt fails, as they recover only the neural implants he needs to set the Pillar of Autumn to self-destruct, destroy Halo 04, and supposedly end this whole nightmare.
Crashed, captured and Floodified.
So perhaps Julie Benz should have known going in that there's a bit of bad luck associated with characters sharing the last name "Keyes" in Halo games.
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